| Mental Health Center | Director |
| Aiken-Barnwell Mental Health Center | Tamara L. Smith |
| Anderson-Oconee-Pickens Mental Health Center | Vicki S. Redding |
| Beckman Center For Mental Health Services | Melanie Gambrell |
| Berkeley Community Mental Health Center | Matthew Dorman |
| Catawba Community Mental Health Center | Tamara M. Edrington |
| Charleston / Dorchester Mental Health Center | Jennifer Roberts |
| Coastal Empire Community Mental Health Center | Angie Salley |
| Columbia Area Mental Health Center | Allison B. Smith, LPCS (Acting) |
| Greater Greenville Mental Health Center | Peter Camelo |
| Lexington County Community Mental Health Center | Sarah Main |
| Orangeburg Area Mental Health Center | Natashia Smith, PhD |
| Pee Dee Mental Health Center | Pat Bresnan |
| Santee-Wateree Mental Health Center | Jeff Ham |
| Spartanburg Area Mental Health Center | Roger Williams |
| Tri-County Community Mental Health Center | Teresa Curry |
| Waccamaw Center For Mental Health | Jackie Brown |
December 2022